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目的 通过了解不同疾病时期系统性红斑狼疮 (SLE)患者血清中白介素 - 18(IL - 18)和可溶性Fas(sFas)及可溶性Fas配体 (sFasL)的变化 ,探讨本病中IL - 18与细胞凋亡的关系。方法 根据SLE疾病活动指数(SLEDAI)评分法 ,将 5 8例SLE患者分为轻、中、重三组 ;应用ELISA方法测定 5 8例SLE患者及 30例正常对照血清IL - 18和sFas及sFasL水平。结果 SLE患者血清中IL - 18和sFas水平明显高于正常对照组 (P <0 0 1) ,在疾病活动度轻、中、重三组之间有显著的统计学差异 (P <0 0 1)。SLE患者血清中sFasL与正常对照组相比明显增高 (P <0 0 1) ,但各组间无显著差异 (P >0 0 5 )。患者血清IL - 18水平的增高与sFas增高呈正相关 (γ =0 4 96 ,P <0 0 1) ,与sFasL无明显相关 (γ =0 12 6 ,P >0 5 )。结论 SLE患者血清IL - 18的增高可引起sFas和sFasL增高 ,二者在SLE发病机制中起重要作用。
Objective To investigate the changes of interleukin 18 (IL - 18), soluble Fas (sFas) and soluble Fas ligand (sFasL) in patients with systemic lupus erythematosus (SLE) The relationship between apoptosis. Methods Fifty - eight SLE patients were divided into mild, moderate and severe groups according to SLE disease activity index (SLEDAI) score method. Serum levels of IL - 18, sFas and sFasL in 58 SLE patients and 30 normal controls were measured by ELISA. Level. Results The serum levels of IL - 18 and sFas in SLE patients were significantly higher than those in controls (P <0.01), and there was a significant difference between the three groups in disease activity (P <0.01 ). The level of sFasL in serum of patients with SLE was significantly higher than that of the normal controls (P <0.01), but there was no significant difference between the two groups (P> 0.05). Serum levels of IL - 18 were positively correlated with the increase of sFas (γ = 0 496, P 0 01), but not with sFasL (γ = 0 12 6, P 0 05). Conclusion The increase of serum IL - 18 in patients with SLE may lead to the increase of sFas and sFasL, both of which play an important role in the pathogenesis of SLE.