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目的探讨人工流产后继发性不孕患者自身免疫抗体和血清内分泌水平。方法 98例人工流产后继发性不孕患者作为研究组,另选择同期原发性不孕患者95例作为对照a组,同期行孕前检查的正常育龄女性90例作为对照b组;用酶联免疫法检测各组抗卵巢抗体(AOAb)、抗子宫内膜抗体(EMAb)、抗绒毛膜促性腺激素抗体(AHCGAb)、抗精子抗体(ASAb)、抗心磷脂抗体(ACAb)阳性情况,用化学发光法检测各组血清生殖激素雌二醇(E2)、促卵泡生成素(FSH)、促黄体生成素(LH)、泌乳素(PRL)、睾酮(T)、胰岛素(INS)的水平,然后进行比较分析。结果研究组与对照a组、对照b组比较:AOAb、EMAb、AHCGAb阳性反应率均高,差异有统计学意义(P<0.05)、但两组总抗体阳性水平比较差异无统计学意义(P>0.05),研究组、对照a组总抗体水平均显著高于对照b组(P<0.05);血清生殖激素水平比较:研究组E2低于其他各组,促卵泡生成素(FSH)及FSH/LH比值均高于其他各组,差异有统计学意义(P<0.05),而其他生殖激素水平比较差异无统计意义(P>0.05)。结论 AOAb、EMAb、AHCGAb和卵巢储备功能下降可能是人工流产后引起女性继发性不孕的重要因素。
Objective To investigate the autoimmune antibodies and serum endocrine levels in patients with secondary infertility after induced abortion. Methods Ninety-eight cases of post-abortion secondary infertility patients were selected as the study group. Another 95 cases of primary infertility patients were selected as the control group a in the same period, and 90 normal pregnant women in the same period as the control group b. (AOAb), anti-endometrial antibody (EMAb), anti-choriocarcinoma antibody (AHCGAb), anti-sperm antibody (ASAb) and anti-cardiolipin antibody (ACAb) The levels of serum estradiol (E2), follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), testosterone (T) and insulin (INS) For comparative analysis. Results The positive rates of AOAb, EMAb and AHCGAb in study group were significantly higher than those in control group a and control group b (P <0.05), but there was no significant difference between the two groups (P > 0.05). The levels of total antibodies in study group and control group a were significantly higher than that in control group b (P <0.05). The levels of serum reproductive hormones in study group were lower than those in other groups (P <0.05) / LH ratio were higher than the other groups, the difference was statistically significant (P <0.05), while the other reproductive hormone levels were no significant difference (P> 0.05). Conclusions The decrease of AOAb, EMAb, AHCGAb and ovarian reserve may be the important factors that cause female secondary infertility after induced abortion.