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[目的]观察云南白药+三联疗法治疗幽门螺杆菌相关性十二指肠溃疡与德诺+三联疗法等效性。[方法]使用随机平行对照方法,将120例门诊患者按随机数字表法分为两组。阿莫西林,0.5g/次,4次/d;甲硝唑,0.2g/次,4次/d。对照组60例德诺,0.12g/次,4次/d。治疗组60例云南白药,1g/次,4次/d。连续治疗14d为1疗程。观测临床症状、溃疡状况、不良反应。治疗1疗程(14d),判定疗效。[结果]上腹痛治疗组显效39例,有效19例,无效2例,总有效率96.67%;对照组显效28例,有效29例,无效3例,总有效率95.00%。嗳气治疗组显效28例,有效28例,无效4例,总有效率93.33%;对照组显效25例,有效28例,无效7例,总有效率83.33%。反酸治疗组显效26例,有效32例,无效2例,总有效率96.67%;对照组显效23例,有效33例,无效4例,总有效率93.33%。溃疡愈合、HP根除治疗组显效45例,有效10例,无效5例,总有效率96.32%;对照组显效43例,有效9例,无效8例,总有效率86.67%。治疗组疗效与对照组具有等效性(P>0.05)。[结论]云南白药+三联疗法治疗幽门螺杆菌相关性十二指肠溃疡与德诺+三联疗法具有等效性,值得推广。
[Objective] To observe the equivalence of Yunnan Baiyao + triple therapy in the treatment of Helicobacter pylori-associated duodenal ulcer and De Novo + triple therapy. [Methods] Using randomized parallel control method, 120 outpatients were divided into two groups according to random number table. Amoxicillin, 0.5g / time, 4 times / d; metronidazole, 0.2g / time, 4 times / d. Control group, 60 cases of Deno, 0.12g / time, 4 times / d. Treatment group, 60 cases of Yunnanbaiyao, 1g / time, 4 times / d. Continuous treatment 14d for a course of treatment. Observation of clinical symptoms, ulcer status, adverse reactions. Treatment of a course of treatment (14d), determine the efficacy. [Result] The results showed that 39 cases were effective, 19 cases were effective, 2 cases were ineffective and the total effective rate was 96.67%. In the control group, 28 cases were markedly effective, 29 cases were effective, 3 cases were ineffective and the total effective rate was 95.00%. In the treatment group, 28 cases were markedly effective, 28 cases were effective, 4 cases were ineffective, and the total effective rate was 93.33%. In the control group, 25 cases were markedly effective, 28 were effective and 7 were ineffective. The total effective rate was 83.33%. In the acid reflux group, 26 cases were markedly effective, 32 cases were effective, 2 cases were ineffective, and the total effective rate was 96.67%. In the control group, 23 cases were markedly effective, 33 cases were effective and 4 cases were ineffective. The total effective rate was 93.33%. In the group of HP eradication, 45 cases were markedly effective, 10 cases were effective, 5 cases were ineffective and the total effective rate was 96.32%. In the control group, 43 cases were markedly effective, 9 cases were effective and 8 cases were ineffective. The total effective rate was 86.67%. The treatment group and the control group have the same effect (P> 0.05). [Conclusion] Yunnan Baiyao + triple therapy for H. pylori-associated duodenal ulcer is equivalent to de novo + triple therapy and is worthy of promotion.