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Objective: The purpose of this study was to investigate the effect of raloxifene on leptin and insulin-like growth factor- I levels and their relation with the biochemical markers of bone metabolism in postmenopausal women. Study design: Sixty-four women were given 60 mg/d raloxifene for 6 months. Serum leptin, insulin-like growth factor- I, alkaline phosphatase, calcium, osteocalcin, and collagen type I cross-link C-telopeptide levels were measured before and after the treatment. The patients were grouped as obese (body mass index, ≥ 25 kg/m2) or non-obese (body mass index, < 25 kg/m2). Results: The mean basal leptin level was significantly higher (P < .001), and the mean crosslink C-telopeptide level was significantly lower (P = .001) in obese patients. Raloxifene therapy increased leptin levels (P < .001) and decreased insulin-like growth factor- I, alkaline phosphatase, and cross-link C-telopeptide levels significantly (P < .001). There was a strong negative correlation between leptin and cross-link C-telopeptide (r = - 0.703; P < .001). Insulin-like growth factor- I was not correlated with any parameter. Conclusion: Raloxifene increases serum leptin levels while decreasing bone resorption in postmenopausal women.
Objective: The purpose of this study was to investigate the effect of raloxifene on leptin and insulin-like growth factor- I levels and their relation with the biochemical markers of bone metabolism in postmenopausal women. Study design: Sixty-four women were given 60 mg / d raloxifene for 6 months. Serum leptin, insulin-like growth factor- I, alkaline phosphatase, calcium, osteocalcin, and collagen type I cross-link C-telopeptide levels were measured before and after the treatment. The patients were grouped as obese (body mass index, ≥ 25 kg / m2) or non-obese (body mass index, <25 kg / m2) Results: The mean basal leptin level was significantly higher Telopeptide level was significantly lower (P = .001) in obese patients. Raloxifene therapy increased leptin levels (P <.001) and decreased insulin-like growth factor- I, alkaline phosphatase, and cross-link C-telopeptide levels significantly <.001). There was a strong negative correlation between l Insulin-like growth factor- I was not correlated with any parameter. Conclusion: Raloxifene increases serum leptin levels while decreasing bone resorption in postmenopausal women. (r = - 0.703; P <.001)