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流行病学资料证实,乙肝病毒(IIBV)感染后男性易成为乙肝表面抗原(IIBsAg)携带状态,而女性则易产生相应抗体(抗-IIBs)。国外研究双亲IIBsAg/抗-IIBs状态与其子女第二性比率(SSR,活产男婴数/活产女婴数)关系的结果表明,父母双方抗-IIBs均阴性而一方IIBsAg阳性时,SSR最高;父母双方IIBsAg均阴性而一方抗-IIBs阳性时,SSR最低。Blumberg等提出生物学假说,即HBV的抗原与男性相关抗原间存在交叉反应性,以解释这些现象。我们分析了1986年7月～1989年9月出生于我院新生儿的母亲IIBsAg/抗-IIBs状态,以探讨母亲IIBsAg/抗-IIBs与新生儿性别的关系。IIBsAg
Epidemiological data confirmed that the hepatitis B virus (HBV) infection in men easily become hepatitis B surface antigen (IIBsAg) carrying status, while women are easy to produce the corresponding antibodies (anti-IIBs). The results of foreign studies on the relationship between the status of parents IIBsAg / anti-IIBs and their children’s second sex ratio (SSR, live births / live births) showed that SSR was highest when both parents were negative for anti-IIBs and positive for one IIBsAg ; When both parents were negative for both IIBsAg and one of the anti-IIBs was positive, the SSR was the lowest. Blumberg et al. Proposed a biological hypothesis that cross-reactivity exists between HBV antigens and male-related antigens to explain these phenomena. We analyzed the status of mothers IIBsAg / anti-IIBs born in our hospital from July 1986 to September 1989 to investigate the relationship between maternal IIBsAg / anti-IIBs and neonatal sex. IIBsAg