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目的研究血清中C反应蛋白(C-Reactive Protein,CRP)与绝经后妇女冠心病(coronaryheart disease,CHD)之间的关系,并探讨甘油三酯(TG)、胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)以及雌二醇(E2)等生化标志物与绝经后妇女冠心病发生的相关性。方法选取115例绝经后女性住院病人为研究对象,排除其他与CRP升高相关疾病后分为冠心病组和非冠心病组。受检者于清晨空腹卧位抽取肘静脉血,分析TG、TC、HDL-C、LDL-C,同时测定了CRP和E2含量,分析他们与绝经后妇女冠心病之间的关系。结果冠心病组血清CRP水平(6.01±2.58 mg/L)显著高于非冠心病组(1.69±0.93 mg/L);冠心病组TG水平明显高于非冠心病组,但两组TC、HDL-C、LDL-C水平比较,差异均无显著性;冠心病组E2水平低于非冠心病组,差异有显著性。结论血清CRP水平的升高可作为预测绝经后妇女冠心病发生的独立危险因素,而它与血脂、血清雌二醇之间无明显相关性;血清雌二醇与绝经后女性冠心病的发病有明显的关系。
Objective To investigate the relationship between serum C-reactive protein (CRP) and coronary heart disease (CHD) in postmenopausal women and to explore the relationship between triglyceride (TG), cholesterol (TC), high density lipoprotein The relationship between HDL-C, LDL-C, E2 and other biochemical markers of coronary heart disease in postmenopausal women. Methods A total of 115 inpatients with postmenopausal women were enrolled in this study. Patients with coronary heart disease and non-coronary heart disease were excluded after other diseases related to elevated CRP. The subjects took elbow venous blood in the fasting decubitus position in the morning to analyze the contents of TG, TC, HDL-C and LDL-C, and determined the contents of CRP and E2, and analyzed their relationship with coronary heart disease in postmenopausal women. Results The serum level of CRP in CHD group (6.01 ± 2.58 mg / L) was significantly higher than that in non-CHD group (1.69 ± 0.93 mg / L). The TG level in CHD group was significantly higher than that in non-CHD group -C, LDL-C levels, the difference was not significant; E2 levels in patients with coronary heart disease was lower than non-coronary heart disease group, the difference was significant. Conclusions Elevated serum CRP level may be used as an independent risk factor for predicting coronary heart disease in postmenopausal women. However, it has no significant correlation with serum lipids and serum estradiol. Serum estradiol and postmenopausal women have coronary heart disease Obvious relationship.