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作者观察了两批早期酵母重组乙型肝炎疫苗的安全性和长期免疫原性.接种对象是65名丙氨酸转氨酶(ALT)活性正常、血清阴性的健康成人.平均年龄为31.8±7.5岁,其中69%为男性,31%为未孕妇女.接种剂量为10μg(1.0ml),于0、1和6月作三角肌注射.将接种对象分为两组.第1组30人,接种由免疫亲和层析法纯化的疫苗;第2组35人,接种由疏水交互层析法纯化的疫苗.每次接种后记录
The authors observed the safety and long-term immunogenicity of two batches of early yeast recombinant hepatitis B vaccines against 65 healthy adults with normal alanine aminotransferase (ALT) activity and seronegative, with an average age of 31.8 ± 7.5 years, Among them, 69% were male and 31% were non-pregnant women.The inoculation dose was 10μg (1.0ml), which was injected into the deltoid muscle in 0, 1 and 6 months.The inoculated subjects were divided into two groups.The first group consisted of 30 Vaccine purified by immunoaffinity chromatography; Group 2 35, inoculated with vaccine purified by hydrophobic interaction chromatography. Record after each inoculation