Most fault-block reservoirs in Xinmu oilfield belong to heterogeneous sandstone in characters which has low permeability, and reservoir pollution is a common phenomenon in this area. Acidizing deplugging in oil wells has become one of the major measures to improve production efficiency in the field. A compound deplugging technology in high efficiency low corrosion is developed for this kind of low permeability sandstone reservoir. On the basis of profoundly understanding of the reservoir’s physical properties and sensitivity, along with comprehensive analysis of the cause for jams in oil wells, a series of experiments are carried out in order to investigate the dissolution reaction among samples and deplugging inhibitor, sample dissolving speed, formation fluid compatibility, reduction of secondary pollution, etc. Considered reservoir condition in nearby wells the optimized compositional deplugging liquid formula is selected for this reservoir. It is featured by reducing the deplugging reaction speed, extending solution for processing radius, preventing secondary damage in dissolution processing, and removing plug pollution effectively. To implement this high efficiency low corrosion deplugging measure based on reservoir condition in the borehole and nearby wells, a relatively better result of deplugging and production increasing is achieved, which enriches the measures to increase production in Xinmu oilfield, and this method can be applied to other similar oilfields for the purpose of maintaining the crude oil production and providing assistant for increasing the production significantly. Most fault-block reservoirs in Xinmu oilfield belong to heterogeneous sandstone in characters which has low permeability, and reservoir pollution is a common phenomenon in this area. Acidizing deplugging in oil wells has become one major measure to improve production efficiency in the field. A compound deplugging technology in high efficiency low corrosion is developed for this kind of low permeability sandstone reservoir. On the basis of profoundly understanding the reservoir’s physical properties and sensitivity, along with comprehensive analysis of the cause for jams in oil wells, a series of experiments are carried out in order to investigate the dissolution reaction among samples and deplugging inhibitor, sample dissolving speed, formation fluid compatibility, reduction of secondary pollution, etc. It is featured by reducing the deplugging reaction speed, extending solution for processing radius, preventing secondary damage in dissolution processing, and removing plug pollution effectively. increasing is achieved, which enriches the measures to increase production in Xinmu oilfield, and this method can be applied to other similar oilfields for the purpose of maintaining the crude oil production and providing assistant for increasing the production significantly.