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本实验将阿霉素40mg,丝裂霉素10mg、顺铂60mg分别掺入20g骨水泥中,制成标准试样,用细胞培养的方法测得所有的抗癌药物均能从载体中释出,其中以阿霉索骨水泥释药时间最长。体外为14天,体内达35天以上。将抗癌药-骨水泥分别埋入山羊肌肉内,于术后不同时间取出标本观察,发现除丝裂霉素骨水泥外,大多数抗癌药-骨水泥都能被机体耐受。用载抗癌药的骨水泥充填肿瘸术后的骨缺损,抗癌药在局部释出,有利于杀灭局部残存细胞,降低复发率。
In this experiment, adriamycin 40mg, mitomycin 10mg, cisplatin 60mg were incorporated into 20g bone cement, made of standard samples, measured by cell culture all anti-cancer drugs can be released from the carrier , Of which Acinetobladder cement release the longest time. 14 days in vitro, up to 35 days in vivo. The anticancer drug - bone cement were buried in the goat muscle, remove the specimen at different times postoperative observation, found that in addition to mitomycin bone cement, most anticancer agents - bone cement can be body tolerance. Anti-cancer drugs containing bone cement filled lamectomy after the bone defect, anti-cancer drugs in the local release, help to kill the local residual cells, reduce the recurrence rate.