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作者以往发现,某些麻风病人的淋巴细胞在用麻风菌抗原刺激后,氚标记的胸腺嘧啶核苷(~3H-TdR)掺合量反而低于不加抗原的对照培养管.通常对照培养管淋巴细胞自发的~3H-TdR的掺合量很低,故麻风菌抗原的抑制效果常不显著.因此作者用亚适量PHA提高同位素掺合量的基线,探讨麻风菌抗原对PHA刺激后淋巴细胞增殖反应的抑制作用,籍以阐明瘤型麻风免疫不反应的机制.118个麻风病人和37个健康接触者的外周血用聚蔗糖
The authors previously found that some leprosy lymphocytes in the leprosy antigen stimulation, tritiated thymidine (3H-TdR) incorporation is lower than the antigen-free control culture tube is usually controlled culture tube 3H-TdR incorporation in spontaneous lymphocytes is very low, so the inhibitory effect of leprosy antigen is often not significant.Therefore, the authors use suboptimal PHA to increase the baseline of isotope incorporation, and explore the effect of leprosy antigen on PHA-stimulated lymphocytes Proliferation response inhibition, membership to clarify the tumor-type leprosy immunity does not respond to the mechanism .118 leprosy patients and 37 healthy contacts with peripheral blood with sucrose