Structure modeling and spatial epitope analysis for HA protein of the novel H1N1 influenza virus

来源 :Chinese Science Bulletin | 被引量 : 0次 | 上传用户:ysq2009123
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
In recent months,a novel influenza virus H1N1 broke out around the world.With bioinformatics technology,the 3D structure of HA protein was obtained,and the epitope residues were predicted with the method developed in our group for this novel flu virus.58 amino acids were identified as potential epitope residues,the majority of which clustered at the surface of the globular head of HA protein.Although it is located at the similar position,the epitope of HA protein for the novel H1N1 flu virus has obvious differences in the electrostatic potential compared to that of HA proteins from previous flu viruses. In recent months, a novel influenza virus H1N1 broke out around the world. World bioinformatics technology, the 3D structure of HA protein was obtained, and the epitope residues were predicted with the method developed in our group for this novel flu virus. 58 amino acids were identified as potential epitope residues, the majority of which clustered at the surface of the globular head of HA protein. Although it is located in the similar position, the epitope of HA protein for the novel H1N1 flu virus has obvious differences in the electrostatic potential compared to that of HA proteins from previous flu viruses.
其他文献
目的了解云南和山西2地无偿献血人群丙型肝炎病毒(HCV)的基因型分布及其差异。方法采用荧光定量PCR(Q-PCR),对所收集的203份ELISA检测抗-HCV阳性的无偿献血者标本(云南102份,
党的十一届三中全会以来,贵州发生了翻天覆地的变化,全省国民经济迅速发展,人民群众物质文化生活有了很大提高,基础设施建设突飞猛进,各项社会事业不断进步,全省呈现出政治安
摘 要: 本文分析了学困生在数学方面的主要表现,并提出了在数学教学中对学困生渗透“爱”的价值观教育的策略。  关键词: 初中数学教学 学困生 “爱”的价值观教育  我国近代教育学家夏丏尊先生说:“教育没有情感、没有爱,就如同池塘没有水,没有水就不能称其为池塘,没有爱就没有教育。”何谓学困生,即学习困难的学生,是指在知识基础、学习习惯方法、心理素质等方面存在偏离常规的结构性缺陷,智力得不到正常的开发
甜豆腐脑VS.咸豆腐脑  说起这豆腐脑,大概没几位同学没听说过。这玩意儿虽然极其普通,却是个南北通吃的家伙。等等!南北通吃?不服!我们统统不服!有“童鞋”马上站出来:“我们这儿的豆腐脑是甜的!冬天浇上红糖姜水暖胃暖心,夏天冰镇豆腐脑配着红豆、绿豆、葡萄干、杏仁片清甜爽口……”“甜豆腐脑‘神马鬼’!”立马有人打断:“难道豆腐脑不应该成得天经地义?你看我一碗白嫩的豆腐脑,配着深棕的酱油,暗金的麻油,米
本刊自1998年第9期发出“读者意见表”调查后,截至10月中旬,共收到读者反馈意见337份。这些读者遍及各行各业,文化程度由初中到研究生,年龄最长者73岁,最小的才13岁。反馈意
教师与学生、学生与学生在一定的情景中,围绕多元目标,在开展合作、对话、探究、交流的课堂教学中,即时生成的、超出教师预设方案之外的新问题、新情况。而问题式的教学能够
随着新课标的改革,教学目标有所改变,而以往初中体育只是一堂仅仅让学生放松的课程,现在它的教学也成为教育的重要组成部分,因为体育教学对学生的综合素质能够产生非常大的影
乙型肝炎病毒(HBV)感染有很高的慢性化趋势,而肝纤维化是慢性肝病向肝硬化发展的必经阶段〔1〕。但是早期肝脏慢性损伤过程中细胞外基质积累所形成的肝纤维化是可以逆转的,而
Ay4?j;k二/】一。《十【D刃人【丫S_声“人TInyLlkrh厂wyxcotrN毛_A。1/””·/祝贺《河北教育》创刊50周年 Ay4? J; k two / one. “Ten blade people 【Ah S_ sound” TIn
期刊
近日,读了唐庆华先生写的《哈佛大学亲历记》(1997年第3期《书摘》),印象颇深,因为本刊的办刊方法与哈佛的教学方法不谋而合,均注重从分析实例入手。这不是很有趣吗? 号称资