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微操控技术是指精确控制微纳米颗粒的运动状态,如对细胞、生物大分子、纳米药物等进行捕获、筛选、移动、分类,其在生物医学、化学分析、材料科学等领域有着重要应用,近年来引起了各国学者的极大关注。声操控是利用声波操控微粒,具有非接触、穿透性较好、无需对微粒进行化学生物修饰等优点。近年来随着微机电系统(MEMS)技术和微流控芯片技术的迅速发展,基于声表面波(SAW)的微操控技术受到广泛关注和研究。声表面波芯片因其具有频率较高、能量局域、易于集成等特点,能够基于显微技术直接观察细胞、微泡等生物微粒的操纵状态,是一个良好的微操控工具。文章主要介绍基于声表面波的声流、声辐射力效应操控微粒的最新研究进展以及声操控的发展趋势。
Micromanipulation technology refers to precisely controlling the movement state of micro-nano particles, such as capturing, screening, moving and sorting cells, biological macromolecules and nano drugs, and has important applications in the fields of biomedicine, chemical analysis and material science, In recent years, scholars of all countries have drawn great attention. Acoustic manipulation is the use of sound waves to manipulate the particles, with non-contact, penetrating better, without the need for chemical modification of particles and other advantages. In recent years, with the rapid development of microelectromechanical system (MEMS) technology and microfluidic chip technology, surface acoustic wave (SAW) -based micromanipulation technology has drawn much attention and research. SAW chip is a good tool for micromanipulation because of its characteristics of high frequency, energy localization and easy integration. It can directly observe the manipulation state of biological particles such as cells and microbubbles based on microscopy. This paper mainly introduces the latest research progress of the control particle based on acoustic flow and acoustic radiation force effect and the development trend of acoustic manipulation.