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本文首次评价了APD[(3-氨基-1-羟基亚丙基)-1,1-二磷酸酯]加钙剂与单独钙剂治疗类固醇性骨质疏松的效果。 35例成人慢性肺部疾病、胶原性血管病患者,长期接受超生理量的糖皮质激素。随机每天接受APD(16例)或安慰剂(19例)150mg,共2个月。所有患者均每天补钙剂1.0g。结果显示,APD组患者在头6个月内,的平均掌骨皮质区域增加1.2％(P<0.06),6～12个月无进一步改变。而对照组呈进行性减少,一年时减少1.2％(P<0.05),6、12
This article first evaluated the efficacy of APD [(3-amino-1-hydroxypropyl) -1,1-diphosphate] plus calcium and steroid alone in the treatment of steroid-induced osteoporosis. 35 adult patients with chronic lung disease, collagen-induced vascular disease, long-term super-physiological glucocorticoid. APD (16 patients) or placebo (19 patients) were randomized to receive 150 mg daily for 2 months. All patients were daily calcium supplement 1.0g. The results showed that in the first 6 months, the mean metacarpal cortical area of APD patients increased by 1.2% (P <0.06), with no further change from 6 to 12 months. The control group showed a progressive reduction, a decrease of 1.2% (P <0.05), 6,12