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目的研究胰腺导管癌、癌旁上皮及慢性胰腺炎组织中前列腺干细胞抗原(PSCA)和Oct-4表达及探讨其临床病理意义。方法51例胰腺导管癌、20例癌旁上皮及10例慢性胰腺炎手术切除标本常规石蜡包埋切片,PSCA和Oct-4染色方法为EnVision两步法。结果胰腺导管癌PSCA和Oct-4阳性表达率(52.9%,47.1%)明显高于癌旁上皮(25.0%,20.0%)和慢性胰腺炎(10.0%,10.0%),差异均有显著性意义(P<0.05)。高分化腺癌和无转移胰腺导管癌PSCA和Oct-4表达阳性率明显低于低分化腺癌和转移病例(P<0.05)。结论PSCA和Oct-4表达可能是反映胰腺导管癌发生、进展及预后的重要癌干细胞抗原。
Objective To study the expression of prostate stem cell antigen (PSCA) and Oct-4 in pancreatic ductal carcinoma, paraneoplastic epithelium and chronic pancreatitis and to explore its clinicopathological significance. Methods Totally 51 cases of pancreatic ductal carcinoma, 20 cases of paracancer epithelium and 10 cases of chronic pancreatitis were paraffin-embedded sections. PSCA and Oct-4 staining methods were EnVision two-step method. Results The positive rates of PSCA and Oct-4 in pancreatic ductal carcinoma (52.9%, 47.1%) were significantly higher than those in para-cancerous epithelium (25.0%, 20.0%) and chronic pancreatitis (10.0%, 10.0% (P <0.05). The positive rates of PSCA and Oct-4 expression in well-differentiated adenocarcinoma and non-metastatic pancreatic ductal adenocarcinoma were significantly lower than those in poorly differentiated adenocarcinoma and metastatic adenocarcinoma (P <0.05). Conclusion PSCA and Oct-4 expression may be important cancer stem cell antigens that reflect the occurrence, progression and prognosis of pancreatic ductal carcinomas.