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我国人群中HBsAg携带率达5~20%,这对健康人群形成了很大威胁,尤其是学龄前儿童的HBV易感率可达80%．使用乙肝疫苗主动免疫是控制和预防乙肝病毒感染的主要手段,现国内普遍采用乙肝疫苗接种方案为0、l、6月3次注射法,第2次注射后的抗-HDs阳转率只能达到60%左右,待4个月完成第3针后才能达到70~90%。由于完成全程免疫的时间太长,推迟了接种者抗－HBs水平的产生,不能及时得到保护,同时对乙肝疫苗的保存带来不便。本文为健康儿童及成人共113例乙肝疫苗接种者设计了10μg/次,0、l、2月3次注射新方案,男83例儿童和成人仍按o、l、6月方案接种对照,对缩短免疫时间后的免疫应答效果及安全性进行观察。
HBsAg carrying rate of 5-20% of our population, which pose a great threat to healthy people, especially for preschool children HBV susceptibility up to 80%. The use of active immunization of hepatitis B vaccine is the main means of control and prevention of hepatitis B virus infection, hepatitis B vaccination programs are now commonly used in the country 0,1, June 3 injection method, the second injection of anti-HDs positive rate of rotation only Reached 60%, to be completed in 4 months after the first 3 needles to reach 70 to 90%. Due to the long time to complete the whole immune system, postponing the vaccination anti-HBs levels, can not be protected in time, while the preservation of hepatitis B vaccine inconvenience. In this paper, a total of 113 cases of healthy children and adults with hepatitis B vaccine were designed 10μg / times, 0, l, 3 times a new injection in February, 83 cases of children and adults were still o, l, 6 months program vaccination, Shorten the immunization time after the immune response and safety were observed.