我们自1991年2月～4月对8例胶质母细胞瘤,4例星形细胞瘤进行了瘤内氨甲蝶呤(MTX)含量测定,病人均在术前全麻后给药,共分为3组。Ⅰ组(4例):自颈动脉穿刺后,先注入罂粟碱可逆性开放血脑屏障(罂粟硷0.4mg/kg),30～40秒注完,而后3～5分钟注入 MTX20mg。Ⅱ组(4例):单纯自颈动脉注入MTX20mg,3～5分钟注完。Ⅲ组(4例):自周围静脉 We from February 1991 to April of 8 cases of glioblastoma, 4 cases of astrocytoma tumor methotrexate (MTX) content were measured, the patients were given after preoperative general anesthesia, a total of Divided into 3 groups. Group Ⅰ (n = 4): After the carotid artery puncture, papaverine was first injected into the blood-brain barrier (papaverine 0.4 mg / kg) for 30-40 seconds, followed by MTX 20-3 mg / kg for 3-5 minutes. Group Ⅱ (4 cases): MTX 20 mg was injected from the carotid artery only, and the injection was completed within 3 to 5 minutes. Group Ⅲ (4 cases): from the peripheral vein