肾小球肾炎(GN)是肾功能衰竭而进行肾透析的最常见的原因。这种疾病通常是由免疫复合物引起。免疫复合物可沉积在肾小球的底膜和/或肾小球膜内。任何抗原都可能引起肾小球病变。为什么GN有特殊表现型,原因仍不清楚。免疫反应的变化,抗原自身特性的差异,以及肾小球特性的先天和后天的变化都可能是病因。研究引起GN感染的大量病例为了解这种疾病提供了可能性。1971年,Comkes等描述一名病人在输血4个月后发生乙型肝炎病毒(HBV)感染。一年后, Glomerulonephritis (GN) is the most common cause of renal dialysis in renal failure. The disease is usually caused by immune complexes. Immune complexes can deposit in the glomerular basement membrane and / or the mesangial membrane. Any antigen can cause glomerular lesions. Why GN has a special phenotype, the reason is still not clear. Changes in the immune response, differences in the nature of the antigen itself, and changes in innate and acquired glomerular properties may be the cause. Studying a large number of cases that cause GN infection offers the possibility of understanding the disease. In 1971, Comkes et al. Described a patient who developed hepatitis B virus (HBV) infection 4 months after transfusion. one year later,