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目的对丙型肝炎病毒母婴传播及其机制进行研究。方法联合检测抗-HCV和HCV-RNA确定孕妇和婴儿丙型肝炎病毒（HCV）感染，分析HCV基因型和定量检测孕妇血清中HCV，研究HCV的母婴传播及其影响因素。结果对610名孕妇进行了研究，孕妇HCV感染率为295％（18／610）。对感染HCV的孕妇所生18名婴儿随访12个月，其中5名婴儿感染了HCV。HCV母婴传播率为278％（5／18）。所有孕妇和婴儿均为HCV基因型1b感染。孕妇血清中存在较低水平的HCV（≤14.11×105／ml）。结论孕妇血清HCV低滴度时可以传播HCV于其婴儿。依靠执-HCV和HCV-RNA检测可明确孕妇和婴儿HCV感染，联合检测抗-HCV和HCV-RNA对确定HCV感染有一定的应用价值。
Objective To study the mother-to-infant transmission of hepatitis C virus and its mechanism. Methods Combined detection of anti-HCV and HCV RNA for the detection of hepatitis C virus (HCV) infection in pregnant women and infants, analysis of HCV genotypes and quantification of HCV in pregnant women, and study of the mother-to-infant transmission of HCV and its influencing factors. Results A total of 610 pregnant women were studied. The HCV infection rate of pregnant women was 295% (18/610). Eighteen infants born to pregnant women infected with HCV were followed up for 12 months and five of the infants were infected with HCV. The mother-to-child transmission rate of HCV was 278% (5/18). All pregnant women and infants were infected with HCV genotype 1b. Lower levels of HCV are present in pregnant women’s serum (≤ 14.11 × 10 5 / ml). Conclusion Pregnant women can transmit HCV in their infants with low serum HCV. HCV-RNA and HCV-RNA tests can confirm the HCV infection in pregnant women and infants. The combined detection of anti-HCV and HCV-RNA has certain value in the determination of HCV infection.