4 主要器官的病变特点 了解MSOF时各主要器官功能不全的变化.对临床实践具有指导意义。 4.1 肾功能不全 在各种原因使有效循环血量不足时,最早受到影响的是肾脏。当肾血流减少,超过一定限度、就会导致一些有害物质在体内积滞并造成电解质和酸碱平衡的失调,产生机体中毒.临床上表现为少尿、无尿、血液NPN和肌酐升高.随着时间的推移,进一步加重肾功能不全甚至发生肾衰. 4 lesions of major organs Understanding of MSOF when the main organ dysfunction changes, has guiding significance for clinical practice. 4.1 Renal insufficiency In a variety of reasons to make the effective circulation of blood shortage, the earliest affected by the kidneys. When the renal blood flow decreases, more than a certain limit, it will lead to some of the harmful substances in the body and cause electrolyte imbalance and acid-base balance, resulting in body poisoning .Clinical manifestations of oliguria, anuria, blood NPN and creatinine increased With the passage of time, further aggravating renal insufficiency and even renal failure.