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大量基础和临床试验证明,他汀类药物不仅可以明显改善血脂水平,而且具有多向、多效的非调脂作用,早期应用他汀药可以抗心律失常、改善心功能,降低心血管事件的发生率和死亡率,因此更加广泛的应用于临床。本文即对他汀药非调脂作用及在心血管疾病中临床应用作如下综述。
A large number of basic and clinical trials have shown that statins can not only significantly improve blood lipid levels, but also have a multi-directional and multi-effect of non-lipid-lowering effect. Early application of statins can prevent arrhythmias, improve cardiac function and reduce the incidence of cardiovascular events And mortality, so more widely used in clinical. In this paper, the non-lipid-lowering effects of statins and its clinical application in cardiovascular diseases are summarized as follows.