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探讨小儿初治达完全缓解 (CR)的急性白血病在以后定期化疗中 ,测定化疗前后外周血红细胞超氧化物歧化酶 (SOD)活性及血浆丙二醛 (MDA)的变化。采用黄嘌呤氧化酶比色法测定红细胞SOD活性 ,硫代巴比妥比色法测定血浆MDA含量。结果显示 :30例CR的急性淋巴细胞白血病 (ALL)患儿化疗前SOD正常 ,MDA升高 ;化疗后SOD明显降低 (P <0 .0 1 ) ,MDA明显升高 (P <0 .0 1 )。结论 :检测急性白血病患儿化疗前后SOD、MDA的变化 ,可作为反映化疗药物引起组织细胞损伤的指标之一。
To investigate the changes of peripheral blood erythrocyte superoxide dismutase (SOD) activity and plasma malondialdehyde (MDA) before and after chemotherapy in the treatment of acute leukemia with initial complete remission (CR) in children. The activity of SOD in erythrocytes was determined by xanthine oxidase colorimetry, and the level of plasma MDA was measured by thiobarbituric colorimetry. The results showed that: 30 cases of CR children with acute lymphoblastic leukemia (ALL) before chemotherapy, normal, MDA increased; SOD decreased significantly after chemotherapy (P <0.01), MDA was significantly increased (P <0.01 ). Conclusion: The changes of SOD and MDA in children with acute leukemia before and after chemotherapy can be used as one of the indicators to reflect the cell injury caused by chemotherapy drugs.