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糖尿病是对人类健康有严重威胁,对社会发展有重大影响的疾病。大多数糖尿病患者死亡与致残的原因为大血管动脉粥样硬化并发症。在动脉粥样硬化性病变的进展过程中,一个关键的步骤就是易损斑块的形成。巨噬细胞凋亡与易损斑块形成密切相关。在晚期动脉粥样硬化病变处,多种信号途径诱导巨噬细胞凋亡,其中内质网应激(ERS)起重要作用。在高血糖、胰岛素抵抗状态下,ERS诱导的巨噬细胞凋亡增加,促进易损斑块的形成,加速动脉粥样硬化性血管疾病的进程。
Diabetes is a serious threat to human health, social development has a significant impact on the disease. The cause of death and disability in most diabetic patients is macrovascular atherosclerotic complications. A key step in the development of atherosclerotic lesions is the formation of vulnerable plaque. Macrophage apoptosis is closely related to the formation of vulnerable plaque. In advanced atherosclerotic lesions, a variety of signaling pathways induce apoptosis in macrophages, of which endoplasmic reticulum stress (ERS) plays an important role. Under hyperglycemia and insulin resistance, ERS-induced apoptosis of macrophages increases, promotes the formation of vulnerable plaque and accelerates the process of atherosclerotic vascular disease.