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目的:通过对冠心病患者与健康对照组之间的比较,分析血清瘦素与多种影响因素关系。方法:测定91例男性冠心病患者及123例男性正常人的血清瘦素浓度(Lep)、空腹胰岛素(FIN)、收缩压(SBP)、舒张压(DBP)、体重指数(BMI)、空腹血糖(FPG)、总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)等指标。血清瘦素用酶联吸附免疫分析法(ELISA 法)测定。稳态模式评估法计算胰岛素抵抗指数(HOMA-IR)。分析血清瘦素与其它各项参数的相关性。结果:冠心病组 Lep、TG 均较对照组高,其差异有统计学意义(P<0.05);多元相关分析显示,瘦素水平与 BMI、TG、FIN、HOMA-IR 呈明显正相关(r=>0.45,P<0.001)。结论:冠心病患者与正常人群中血清瘦素水平存在明显差异。高瘦素水平与血脂、胰岛素抵抗密切相关并可能与其有协同关系,共同促进了冠心痛事件的发生。
Objective: To compare the relationship between serum leptin and various influencing factors by comparing coronary heart disease patients with healthy control group. Methods: The serum levels of leptin, FIN, SBP, DBP, BMI, fasting plasma glucose (FBG), serum creatinine FPG, TC, TG, HDL, LDL and so on. Serum leptin was detected by enzyme-linked immunosorbent assay (ELISA). Steady-state model assessment of insulin resistance index (HOMA-IR). Analysis of serum leptin and other parameters of the correlation. Results: The levels of Lep and TG in CHD group were significantly higher than those in control group (P <0.05). Multivariate correlation analysis showed that there was a significant positive correlation between leptin level and BMI, TG, FIN and HOMA-IR => 0.45, P <0.001). Conclusion: Serum leptin levels in patients with coronary heart disease and normal population are significantly different. High leptin levels and blood lipids, insulin resistance are closely related and may have synergies with them, and jointly promote the occurrence of coronary heart disease.