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深入探索炎症性肠病(IBD)的免疫学变化,对明确其病因及发病机理有重要意义。系统性免疫学方面的改变早年众多学者曾对IBD 的系统性免疫学做了大量详尽的研究。有作者发现IBD 患儿的血清中有能与人结肠提取物起反应的抗结肠抗体(ACA)。它们是IgG-ACA 和IgM-ACA。无菌大白鼠结肠与大肠杆菌O_(14)使机体致敏,并产生ACA,从而发生一系列免疫损伤。IBD患者的循环中有IgG 的免疫复合物,并认为IBD 的某些肠外表现与循环内免疫复合物有关。IBD 不仅仅有体液免疫功能方面的异常,细胞免疫功能方面也有异常。有作者用混合
In-depth exploration of inflammatory bowel disease (IBD) immunological changes, to clarify its etiology and pathogenesis is of great significance. Systematic Immunology Changes Many early researchers have done a great deal of exhaustive research on systemic immunology in IBD. It has been found in the sera of IBD children that there is an anti-colon antibody (ACA) that reacts with human colon extract. They are IgG-ACA and IgM-ACA. Aseptic rat colon and E. coli O_ (14) sensitize the body and produce ACA, resulting in a series of immune damage. IBD patients have circulating IgG IgG immune complexes, and that some of IBD’s extranodal manifestations are associated with circulating immune complexes. IBD is not only abnormal in humoral immune function, but also abnormal in cellular immune function. There are authors mixed