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目的探讨急性动脉粥样硬化性脑梗死(acute atherothrombotic ischemic cerebral infarction)患者中血清C-反应蛋白(C-reactive protein,CRP)水平与神经功能缺损(neurological impairment)程度及日常生活活动能力(Barthel指数)的相关性。方法收集急性动脉粥样硬化性脑梗死患者138例,所有患者入院当天均接受神经功能缺损程度与Barthel指数评分,根据评分结果的不同进行分组,采集第2天清晨空腹血测定CRP浓度,然后进行分析比较。结果在急性动脉粥样硬化性脑梗死患者中,中国人卒中量表(Chinese stroke scale,CSS)重型患者血清CRP水平高于CSS中型患者(P<0.05),CSS中型患者血清CRP浓度大于CSS轻型患者(P<0.05),CSS重型患者血清CRP浓度明显大于CSS轻型患者(P<0.05);Barthel指数级别为良的患者CRP浓度低于级别为差的患者(P<0.05),Barthel指数级别为良的患者CRP浓度低于级别为中的患者(P<0.05),Barthel指数级别为中的患者CRP浓度低于级别为差的患者(P<0.05),具有统计学意义。结论在急性动脉粥样硬化性脑梗死患者中,血清CRP水平与神经功能缺损程度呈正相关,与Barthel指数呈负相关。
Objective To investigate the relationship between the level of C-reactive protein (CRP) and the degree of neurological impairment and the activity of daily living in patients with acute atherothrombotic ischemic cerebral infarction (Barthel index ) Relevance. Methods A total of 138 patients with acute atherosclerotic cerebral infarction were collected. All patients were admitted on the day of admission with the degree of neurological deficit and Barthel index score, and were divided into groups according to the score results. The fasting blood samples of the second day were collected for determination of CRP concentration before proceeding analyse and compare. Results In patients with acute atherosclerotic cerebral infarction, serum CRP levels were significantly higher in Chinese stroke scale (CSS) severe patients than in CSS moderate disease patients (P <0.05). Serum CRP concentrations in CSS moderate patients were higher than those in CSS light (P <0.05). The serum CRP levels in CSS heavy patients were significantly higher than those in CSS light patients (P <0.05). The patients with good Barthel index were lower than those with poor grades (P <0.05), Barthel index was Patients with good CRP levels were lower than those with moderate levels (P <0.05). CRBP levels were lower in patients with Barthel index than in patients with poor levels (P <0.05). Conclusion In patients with acute atherosclerotic cerebral infarction, serum CRP level is positively correlated with the degree of neurological deficit, and negatively correlated with Barthel index.