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目的探讨口服避孕药(Oral Contraceptive,OC)暴露、纤溶酶原激活物抑制剂1(Plasminogen Activator Inhibitor-1,PAI-1)基因多态性联合作用与中国女性脑卒中发病风险的关系。方法采用Taqman-MGB方法和普通聚合酶链式反应(Polymerase Chain Reaction,PCR)方法检测PAI-1位点各基因型频率。结果服用OC女性脑卒中发病风险明显升高(OR=1.31;95%CI:1.01~1.71)。与4G4G基因型相比,携带rs1799889位点5G/5G基因型显著降低梗塞型脑卒中的发病风险(OR=0.35;95%CI:0.18~0.67)。与未服用OC且不携带4G等位基因的妇女相比,服用OC同时携带rs1799889位点5G等位基因可降低梗塞型脑卒中的发病风险(OR=0.53;95%CI:0.34~0.83)。结论服用OC会显著增加中国女性脑卒中的发病风险;PAI-1基因多态性与中国女性梗塞型脑卒中发病有关;OC与PAI-1基因多态性之间的联合作用会与女性脑卒中的发病风险存在关联。
Objective To investigate the relationship between Oral Contraceptive (OC) exposure, Plasminogen Activator Inhibitor-1 (PAI-1) gene polymorphism and the risk of stroke in Chinese women. Methods The genotype frequency of PAI-1 locus was detected by Taqman-MGB and Polymerase Chain Reaction (PCR). Results The incidence of stroke in OC women was significantly higher (OR = 1.31; 95% CI: 1.01-1.71). Compared with 4G4G genotype, 5G / 5G genotype rs1799889 significantly reduced the incidence of stroke (OR = 0.35; 95% CI: 0.18-0.67). Compared with women who did not take OC and did not carry 4G allele, taking OC together with 5G allele at rs1799889 reduced the risk of stroke (OR = 0.53; 95% CI: 0.34-0.83). Conclusions OC may significantly increase the risk of stroke in Chinese women. The polymorphism of PAI-1 is associated with the onset of stroke in Chinese women. The combined effect of OC and PAI-1 genetic polymorphisms may be associated with stroke in women The incidence of risk is related.