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本文根据四环素碱的化学结构特点和尿素的化学性质,选用了尿素复盐水重结晶工艺,提高四环素碱的质量,控制了4-差向四环素的含量,并提出了加强粗碱的工艺控制。
According to the chemical structure of tetracycline base and the chemical properties of urea, urea reclaimed water recrystallization process was used to improve the quality of tetracycline base and control the content of 4-epi-tetracycline, and the process control of crude base was proposed.