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韦格氏肉芽肿(WG)是一种病因不明的系统性疾病。临床特征是坏死性炎性肉芽肿,组织坏死,不同程度的中小血管病变。临床表现涉及上呼吸道、肺脏及肾脏病变。WG的诊断依据临床表现和实验室检查。如果患者出现典型的三联症上呼吸道症状、肺部症状和肾脏症状且ANCA阳性,不需要活检就能确诊。在最近几年,韦格内肉芽肿的治疗出现了一种降低剂量综合措施的新标准。通过两个阶段的治疗达到这些目标:诱导缓解阶段,及随后的维持缓解阶段。在诱导阶段,目前短疗程联合应用糖皮质激素和环磷酰胺。在诱导病情缓解成功后,治疗的核心转向维持阶段即糖皮质激素减量期。
Wegener’s granulomatosis (WG) is a systemic disease of unknown etiology. Clinical features are necrotizing inflammatory granuloma, tissue necrosis, varying degrees of small and medium vascular lesions. Clinical manifestations involve upper respiratory tract, lung and kidney disease. The diagnosis of WG is based on clinical manifestations and laboratory tests. If you have a classic triad of upper respiratory symptoms, lung symptoms, and kidney symptoms that are ANCA positive, you can be diagnosed without a biopsy. In recent years, the treatment of Wegener’s granulomatosis has emerged as a new standard for reducing the combined dosage measures. These goals are met by two stages of treatment: induction of remission and subsequent maintenance of remission. In the induction phase, the current short course of combination of glucocorticoid and cyclophosphamide. After induction of the disease to ease the success, the treatment of the core shift to the maintenance phase of glucocorticoid reduction period.