免疫闪烁法后,卵巢癌患者会产生人抗鼠抗体(HAMA)。据报道产生大量HAMA的患者,长期存活率升高,这可能与基因型网状结构的诱导有关。为此,作者检测了卵巢癌患者产生HAMA之前及其产生过程中的外周血淋巴细胞(PBL)的表型和功能,并将这些免疫学参数与临床病程进行比较。用蛋白质G亲和层析法去除HAMA后,对淋巴细胞仪 After immunostaining, ovarian cancer patients produce human anti-mouse antibody (HAMA). Long-term survival has been reported in patients with large HAMA, which may be related to the induction of genotypic reticular formation. To do this, the authors examined the phenotype and function of peripheral blood lymphocytes (PBLs) before and during HAMA production in ovarian cancer patients and compared these immunological parameters with clinical course. After removal of HAMA by protein G affinity chromatography, the lymphocytes were analyzed