在高血压及多种其他心肾血管疾病的发病机制中 ,肾素、血管紧张素系统 (ＲＡＳ)起着重要的作用。血管紧张素Ⅱ (ＡｎｇⅡ )作为主要内分泌激素之一在体内有多种重要的功能 ,在循环水平 ,它促进血管的收缩 ,增高交感神经兴奋性及刺激醛固酮释放致水钠潴留。在细胞水平 ,ＡｎｇⅡ The renin, angiotensin system (RAS) plays an important role in the pathogenesis of hypertension and many other cardiovascular and renal diseases. Angiotensin Ⅱ (AngⅡ), as one of the major endocrine hormones, has a variety of important functions in vivo. At the level of circulation, it promotes blood vessel contraction, increases the excitability of sympathetic nerves and stimulates the release of aldosterone to cause sodium and water retention. At the cellular level, Ang II