目的　研究肝血管病变与肝损伤的关系．方法　肝病变标本２０００ 例，用ＨＥ、免疫组化及电镜技术进行研究．结果　在急性肝炎肝血管炎症、破坏及阻塞随肝坏死加重而上升（ Ｐ＜ ０－０１） ；在慢性肝炎肝血管炎症、破坏、阻塞及增生随肝病变的轻重程度而示梯度变化（ Ｐ＜ ０－０１） ；在肝硬变肝血管增生及纤维化最明显，与结节大小及纤维带宽窄相关（ Ｐ＜ ０－０１） ，伴弹力纤维化． 免疫组化示纤维带、血管内皮细胞及成肌纤维细胞αＳＭＡ 强阳性； 电镜示血管内皮细胞出芽并形成管状结构．结论　肝血管病变在各型肝病变中担当一关键角色 Objective To study the relationship between hepatic vascular lesions and liver injury. Methods Two hundred and twenty-five liver specimens were obtained and studied by HE, immunohistochemistry and electron microscopy. Results The hepatic vascular inflammation, destruction and obstruction increased with the aggravation of hepatic necrosis in acute hepatitis (P <0-01). The changes of hepatic vascular inflammation, destruction, obstruction and hyperplasia showed a gradient change with the severity of liver disease in chronic hepatitis (P < 0-01). Hepatic cirrhosis with the most obvious hepatic vascular hyperplasia and fibrosis was related to the nodule size and narrowing of the fiber bandwidth (P <0-01), accompanied by elastic fibrosis. Immunohistochemistry showed that the fiber band, vascular endothelial cells and myofibroblasts αSMA strong positive; electron microscopy showed vascular endothelial cell budding and the formation of tubular structure. Conclusion Hepatic vascular lesions play a key role in various liver diseases