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目的探讨系统性纵膈淋巴结清扫切除术联合放化疗用于非小细胞肺癌治疗对患者血清癌胚抗原(CEA)、神经特异性烯醇化酶(NSE)及糖类抗原(CA242)水平的影响。方法将206例非小细胞肺癌患者随机分为系统性淋巴结清扫术治疗的研究组和单纯肺门淋巴结清扫术治疗的对照组,每组各103例,2组均采用相同的放化疗治疗方案,分别在治疗前后检测2组患者血清CEA、NSE及CA242水平。结果治疗前2组患者血清CEA、NSE、CA242水平差异无统计学意义(P>0.05);治疗后2组患者血清CEA、NSE及CA242水平均较治疗前降低,且研究组低于对照组,差异均有统计学意义(P<0.05)。结论系统性纵膈淋巴结清扫切除术联合放化疗对非小细胞肺癌患者进行治疗,能有效的降低患者血清CEA、NSE及CA242水平。
Objective To investigate the effect of systemic mediastinal lymphadenectomy combined with chemoradiotherapy on the levels of serum carcinoembryonic antigen (CEA), neuron specific enolase (NSE) and carbohydrate antigen (CA242) in patients with non-small cell lung cancer. Methods A total of 206 patients with non-small cell lung cancer were randomly divided into two groups: study group treated with systemic lymphadenectomy and control group treated with simple hilar lymph node dissection. Each group had 103 cases. The two groups were treated with the same radiotherapy and chemotherapy regimen, Serum levels of CEA, NSE and CA242 were measured before and after treatment in two groups. Results There was no significant difference in serum CEA, NSE and CA242 levels between the two groups before treatment (P> 0.05). Serum levels of CEA, NSE and CA242 in two groups after treatment were lower than those before treatment, and the levels in the study group were lower than those in the control group The differences were statistically significant (P <0.05). Conclusions Systematic mediastinal lymphadenectomy combined with chemoradiotherapy for non-small cell lung cancer patients can effectively reduce the serum CEA, NSE and CA242 levels.