家族性系统性红斑狼疮(SLE),已报道过多次,且常多推测遗传因素是其病因。同样,对家族中未发病的亲属也进行过大量的而结果变化很大的血清学异常的研究。也有报告认为本病与怀孕影响有关。然而对于遗传因素与环境因素的相对重要性迄今尚不明确。为了进一步弄清这个问题,作者对8个家族(每家均有2个SLE的患者)进行了广泛的估价。此外,对一对死亡病例及文献中叙述的31个家 Familial Systemic Lupus Erythematosus (SLE), has been reported many times, and often speculate genetic factors is the cause. Similarly, a large number of serological abnormalities with widely varying outcomes have also been studied in unaffected relatives of the family. There are also reports that the disease and the impact of pregnancy. However, the relative importance of genetic and environmental factors is not yet known. To further clarify this issue, the authors have extensively evaluated 8 families, each with 2 SLE patients. In addition, a pair of deaths and 31 homes described in the literature