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研究人员在近期出版的《免疫学杂志》上报道,1型糖尿病患者在T淋巴细胞表达酪氨酸激酶p56(lck)方面存在一种特殊的缺陷。研究人员发现,某些1型糖尿病患者的T淋巴细胞对TCR/CD3介导的兴奋剂表现出较低的增生和细胞因子生成反应。各种试验结果均表明这种缺陷可能与糖尿病的发生有关。
In a recent issue of the Journal of Immunology, the researchers reported that patients with type 1 diabetes had a particular defect in the expression of tyrosine kinase p56 (lck) in T lymphocytes. The researchers found that T lymphocytes in some type 1 diabetic patients showed lower proliferative and cytokine responses to TCR / CD3-mediated agonists. Various experimental results show that this defect may be related to the occurrence of diabetes.