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人类原发性高血压具有很强的遗传因素。利用实验大鼠和小鼠进行的遗传选择实验已经反复地表明,血压是一个多基因性状,能对遗传选择做出反应。现已培育出了遗传上具有高血压性状的几个不同品系的大鼠和小鼠及具有正常血压的品系。可除了积累一些有效的生化和生理数据外,人们却很少注意去识别血压调节基因。测定限制性内切酶片段长度多态性(RF-LP)的技术使得识别控制不同品系实验动物血压差异基因组成为可能。由于大多数的
Human essential hypertension has a strong genetic factor. Genetic selection experiments using experimental rats and mice have repeatedly shown that blood pressure is a polygenic trait that responds to genetic selection. Several different strains of rats and mice, genetically hypertensive, have been bred and strains with normotensive blood pressure have been developed. In addition to accumulating some valid biochemical and physiological data, people pay little attention to identifying blood pressure regulating genes. Techniques for determining restriction fragment length polymorphism (RF-LP) make it possible to identify differential blood pressure control genomes in different strains of laboratory animals. Because of the majority