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1958年Butler和Flynm指出肾小球损伤和肾小管损伤的尿蛋白成分不同,因而用来区别肾小管性蛋白尿与肾小球性蛋白尿,目前据据其产生机理把肾性蛋白尿分成以上2种类型。在肾小管性蛋白尿,有很多蛋白成分排泄于尿中,用免疫电泳就能鉴定出30种左右的成分。其中量最多的是β_2微球蛋白,免疫球蛋白的轻链,溶菌酶,视网膜结合蛋白等,最近作者等分离出来的α_1微球蛋白(分子量33,000)也证明在尿中大量排出。这些成分都存在于正常人的血浆中,正常人的尿中也可见到。由此可见,肾小管性蛋白尿的LMW(低分子)蛋白的大部分不是由肾脏的异常所产生,而是因正常血浆成分在肾小管的处理异常而出现,易通过正常肾小球的LMW蛋白因肾小管重吸收功能
1958 Butler and Flynm pointed out that different components of urinary protein in glomerular injury and tubular injury, which is used to distinguish between tubular proteinuria and glomerular proteinuria, according to its mechanism of production according to the renal proteinuria into more than 2 types. In tubular proteinuria, there are many protein components excreted in the urine, using immunoelectrophoresis can identify about 30 kinds of ingredients. Among them, β 2 microglobulin, light chain of immunoglobulin, lysozyme, retinal binding protein and so on are the most abundant. The α 1 microglobulin (molecular weight 33,000) isolated recently by author also proves that it is excreted in urine. These ingredients are present in normal human plasma, normal urine can be seen. Thus, most of the LMW (low molecular weight) protein of renal tubular proteinuria is not generated by the abnormalities of the kidneys, but due to the abnormal processing of normal plasma components in the renal tubules, easy to pass through the normal glomerular LMW Protein tubular reabsorption function