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目的研究丙型肝炎病毒(HCV)感染与糖尿病发生的关系。方法用高度灵敏的第3代抗-HCV检测试剂,测定533例2型糖尿病患者(A组)、285例普通体检人群(B组)和862例无慢性肝病的非糖尿病患者(C组)血清抗-HCV,比较抗体阳性率差异,并分析HCV易患因素。结果A组抗-HCV阳性7例,阳性率1.31%,B组和C组分别为2例(0.70%)和5例(0.58%),组间比较,无统计学差异(P>0.05)。糖尿病患者HCV感染与年龄、病程和手术史有关(P<0.01)。糖尿病合并HCV感染者与单纯HCV感染者肝功能改变差异无统计学意义。结论我国HCV感染在糖尿病发生中的作用较小,对糖尿病患者无需常规检测抗-HCV。
Objective To study the relationship between hepatitis C virus (HCV) infection and diabetes mellitus. Methods 533 patients with type 2 diabetes mellitus (group A), 285 patients with general medical examination (group B) and 862 patients with non-diabetic liver disease without chronic liver disease (group C) were assayed with the highly sensitive third generation anti-HCV test reagent Anti-HCV, antibody positive rate differences, and analysis of HCV risk factors. Results The positive rate of anti-HCV in group A was 7 cases, the positive rate was 1.31%. There were 2 cases (0.70%) and 5 cases (0.58%) in group B and C respectively. There was no significant difference between groups (P> 0.05). HCV infection in diabetic patients was related to age, duration of disease and surgical history (P <0.01). There was no significant difference in liver function between diabetic patients with HCV infection and those with HCV infection alone. Conclusions Our country HCV infection plays a minor role in the development of diabetes, and there is no need to routinely detect anti-HCV in patients with diabetes.