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目的：比较地佐辛与哌替啶治疗急性结石性胆绞疼的疗效及不良反应，为急诊临床用药提供参考。方法采用地佐辛+阿托品肌肉注射治疗急性结石性胆绞痛（研究组），以哌替啶+阿托品治为对照组，观察其疗效及药物不良反应。结果研究组与对照组比较，总有效率差异无统计学意义（P>0.05），研究组疼痛复发率降低，与对照组相比，差异具有统计学意义（P<0.05）。恶心呕吐、眩晕、皮肤瘙痒等药物不良反应研究组明显低于对照组，差异具有统计学意义（P0.05), and the relapse rate was significantly lower, the difference had statistical significant (P <0.05). The adverse drug reactions such as nausea, vomiting, dizziness, skin itching etc. test group was significantly lower than the control group, the difference was statistical y significant (P <0.05). Conclusion: Intramuscular injection of dezocine has good analgesic effect in acute cholecyst colic of calculi and it could be used as the treatment of acute cholecyst colic of calculi in emergency department of hospital.