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目的了解浙江省温州地区事业单位女职工子宫颈人乳头瘤病毒(HPV)感染情况与基因型的分布,为该地区HPV分子流行病学研究与子宫颈癌的预防提供一定的科学数据基础。方法 2013年1月至2014年3月,采集来医院做体检的温州地区事业单位女职工5194人的宫颈脱落细胞标本,用导流杂交聚合酶链式反应(PCR)检测HPV基因型的23种亚型,统计分析各高危型、低危型的感染状况,分析不同年龄组间感染率的差异。结果温州地区事业单位女职工子宫颈HPV总感染率为20.91%(1086/5194),高危型感染率为19.23%(999/5194),低危型感染率1.68%(87/5194)。18种高危型均能检测到,感染率居前5位的分别为16型(2.54%)、58型(2.31%)、52型(2.15%)、53型(1.17%)、68型(1.15%);低危型中检出6型、11型、42型,其中感染率最高的是42型(0.69%)。21~30岁、31~40岁、41~50岁、51~60岁年龄段女职工HPV感染率分别为17.30%、13.42%、33.82%、19.71%,41~50岁年龄段感染率显著高于其他年龄段(χ2=9.62,P<0.001)。结论温州地区事业单位女职工宫颈HPV感染具有该人群异质性的流行分布特征,应加强该人群中40~50年龄段HPV感染的预防与监测。
Objective To understand the prevalence and genotypic distribution of cervical human papillomavirus (HPV) among women workers in public institutions in Wenzhou, Zhejiang Province, and to provide some scientific data for HPV molecular epidemiology and prevention of cervical cancer in this area. Methods From January 2013 to March 2014, 5194 female specimens of cervical exfoliative cells from women in Wenzhou area were collected for physical examination. Twenty-three genotypes of HPV were detected by flow-through hybridization polymerase chain reaction (PCR) Subtype, statistical analysis of high-risk type, low-risk type of infection, analysis of different age groups infection rate differences. Results The prevalence of cervical HPV was 20.91% (1086/5194), 19.23% (999/5194) in high-risk women and 1.68% (87/5194) in low-risk women in Wenzhou. Among the 18 high-risk types, the top five infections were detected in 16 (2.54%), 58 (2.31%), 52 (2.15%), 53 (1.17%), 68 %). Type 6, type 11 and type 42 were detected in low-risk type, of which type 42 (0.69%) was the highest. The prevalence of HPV infection in female workers aged 21-30, 31-40, 41-50, 51-60 was 17.30%, 13.42%, 33.82%, 19.71% respectively, and the infection rates were significantly higher in 41-50 age group At other ages (χ2 = 9.62, P <0.001). Conclusion Cervical HPV infection in female employees in public institutions in Wenzhou area has the characteristics of epidemiological distribution of this population heterogeneity. Prevention and monitoring of HPV infection in 40-50 age groups in this population should be strengthened.