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目的 探讨血清总唾液酸（ＴＳＡ） 在预防性体检中应用的可行性及评价其监测恶性肿瘤的临床意义。方法 用化学比色法测定健康年检工人血清ＴＳＡ，分析４８２ 名ＴＳＡ 可疑阳性或阳性工人健康状况，研究２ ３０３ 名交警血清ＴＳＡ 与职业健康监护评定标准的关系、随访１０ ３７３ 名２ ～４ 年前测定血清ＴＳＡ 工人的健康状况、临床观察９４ 例恶性肿瘤患者ＴＳＡ 水平治疗前后变化。结果 （１）ＴＳＡ 在预防性体检中表明：①在４８２ 名ＴＳＡ 可疑阳性或阳性受检者中，肿瘤患者（１０ 例，２－５０ ±０－２１ ｍｍｏｌ／Ｌ） 血清ＴＳＡ 水平高于慢性疾病患者（２４０ 例，２－３９ ±０－２５） ，而后者又明显高于未患病的追踪观察者（２３２ 例，２－１４ ±０－２４） ，Ｐ＜ ０－００１ ；②按照广州市职业健康监护标准发现２ ３０３ 名广州交警血清ＴＳＡ 水平健康组明显低于异常组、追踪观察组和尚健康组，Ｐ＜ ０－０５ 或Ｐ＜ ０－００１ ；③随访发现，原ＴＳＡ 可疑阳性或阳性者新患恶性肿瘤和非恶性肿瘤疾病者明显高于ＴＳＡ 阴性者（ Ｐ＜ ０－００１） 。（２） 在肿瘤监测中发现：９４ 例恶性肿瘤患者ＴＳＡ 水平明显高于健康对照组，病人治疗后病情稳定或好转者ＴＳＡ 明显下
Objective To explore the feasibility of using serum total sialic acid (TSA) in preventive physical examination and to evaluate its clinical significance in monitoring malignant tumors. Methods Chemical serum colorimetry was used to determine the serum TSA of healthy workers, and the health status of 482 suspected TSA positive or positive workers was analyzed. The relationship between 2 303 traffic police serum TSA and occupational health care evaluation criteria was studied. Follow-up was 10 373 people 2 to 4 years ago. The health status of serum TSA workers was measured, and changes in TSA levels in 94 patients with malignant tumors before and after treatment were observed clinically. Results (1) TSA showed in preventive physical examination: 1 Among 482 suspected TSA suspect positive or positive subjects, tumor patients (10 cases, 2-50 ±0-21 mmol/L) had higher serum TSA levels than chronic diseases. Patients (240 cases, 2-39 ± 0-25), and the latter were significantly higher than the non-affected tracking observers (232 cases, 2-14 ± 0-24), P < 0-001; 2 according to Guangzhou City The occupational health monitoring standard found that 2 303 Guangzhou traffic police serum TSA levels in the healthy group were significantly lower than the abnormal group, follow-up observation group and still healthy group, P<0-05 or P<0-001; 3 follow-up found that the original TSA suspicious positive or positive New cancer patients and non-malignant tumors were significantly higher than those with negative TSA (P < 0-001). (2) In tumor monitoring, the TSA levels in 94 patients with malignant tumors were significantly higher than those in the healthy control group. Patients with stable or improved TSA after treatment were significantly reduced.