论文部分内容阅读
子宫内膜异位症(endometriosis,EMS)在生育年龄妇女中多发且发病率呈上升趋势,但其具体机制未完全明确,近年国内外学者研究表明EMS中存在的多种细胞凋亡/存活信号转导通路的异常,这些通路的异常启动及其复杂的相互作用会导致异位内膜组织的异常增殖、分化、侵入性增强及炎症反应,促进异位病灶形成,引起不孕、宫腔粘连、痛经等,对患者身心及经济带来极大挑战。因此,进一步研究EMS有关的信号通路对其所致的不孕症的临床治疗提供可靠依据,本文就EMS有关的MAPs通路、PI3K/AKT(PKB)通路、腺上皮-间质相互作用通路、Rho/ROCK通路的研究进展作一综述。
Endometriosis (EMS) frequently occurs in women of childbearing age and its incidence is on the rise, but its exact mechanism is not completely clear. In recent years, many scholars in China and abroad have shown that various apoptosis / survival signals exist in EMS Abnormalities in the transduction pathways, abnormal activation of these pathways and their complex interactions can lead to abnormal proliferation, differentiation, invasiveness and inflammatory reaction of ectopic endometrial tissues, promote the formation of ectopic lesions, cause infertility and intrauterine adhesions , Dysmenorrhea, etc., pose great challenges to the patient’s body, mind and economy. Therefore, to further study the EMS-related signaling pathways to provide a reliable basis for the clinical treatment of infertility caused by it. In this paper, EMS related MAPs pathway, PI3K / AKT (PKB) pathway, glandular epithelial-interstitial interaction pathway, Rho / ROCK pathway is reviewed.