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目的探讨络脉舒通对兔急性心肌梗死(AMI)再灌流损伤心脏功能和氧自由基的影响。方法新西兰大白兔24只,随机分为络脉舒通组、对照组和假手术组,每组8只,制备AMI再灌流模型。观察各组血流动力学改变,检测丙二醛(MDA)、超氧化物岐化酶(SOD)和一氧化氮合酶(NOS)的变化,测量心肌梗死面积。结果(1)与对照组相比,络脉舒通组缺血-再灌流后2h左室收缩压(LVSP)和左心室内压最大收缩和舒张变化速率(±dp/dt_(max))均显著升高(P<0.05),LVEDP则显著下降(P<0.05)。(2)对照组MDA含量比假手术组显著增高(P<0.05),而SOD和NOS活性均显著降低(P<0.05);与对照组相比,络脉舒通组心肌梗死面积显著缩小(P<0.05),心肌MDA含量显著降低(P<0.05),心肌SOD和NOS活性均显著增高(P<0.05)。结论络脉舒通具有清除氧自由基作用,可以减轻心肌再灌流损伤,改善心功能。
Objective To investigate the effect of Luomaishutong on cardiac function and oxygen free radicals in rabbits after acute myocardial infarction (AMI) reperfusion injury. Methods Twenty-four New Zealand white rabbits were randomly divided into Luomaishutong group, control group and sham operation group, with 8 rats in each group. The AMI reperfusion model was established. Hemodynamic changes in each group were observed, and changes in malondialdehyde (MDA), superoxide dismutase (SOD), and nitric oxide synthase (NOS) were measured to measure myocardial infarct size. Results (1) Compared with the control group, the maximum systolic and diastolic rate of left ventricular systolic pressure (LVSP) and left ventricular pressure 2 hours after ischemia-reperfusion in Luomaishutong group (±dp/dt_(max)) Significantly increased (P <0.05), LVEDP was significantly decreased (P <0.05). (2) The content of MDA in the control group was significantly higher than that in the sham operation group (P<0.05), but the SOD and NOS activities were significantly decreased (P<0.05). Compared with the control group, the infarct size of the Luomaishutong group was significantly reduced (P<0.05). P<0.05), myocardial MDA content was significantly decreased (P<0.05), and myocardial SOD and NOS activity were significantly increased (P<0.05). Conclusion Luomaishutong has the effect of scavenging oxygen free radicals, which can reduce the reperfusion injury of myocardium and improve cardiac function.