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目的探讨分析心肌酶谱检测在轮状病毒腹泻患儿诊断中的临床意义。方法对189例患儿的轮状病毒抗原进行检查,将轮状病毒抗原阳性患儿106例设为观察组,轮状病毒抗原阴性患儿83例设为对照组。对两组患儿的乳酸脱氢酶(LDH)、谷草转氨酶(AST)、同工酶(CK-MB)、肌酸激酶(CK)和α-羟丁酸脱氢酶(α-HBDH)这5项心肌酶谱进行检测,观察对比两组患儿的心肌酶谱水平。结果观察组106例轮状病毒感染患者中,心肌酶谱表现异常者72例,发生率达67.92%,而对照组83例患儿的心肌酶谱均处于正常水平,观察组患者的CK、AST、CK-MB、α-HBDH水平明显高于对照组,差异具有显著性。结论心肌酶谱与轮状病毒引起的腹泻有一定相关性,对患儿做血清心肌酶谱检测,有助于及时发现婴幼儿的心肌损害,为该疾病的临床诊断及治疗提供依据。
Objective To investigate the clinical significance of myocardial enzyme detection in the diagnosis of rotavirus diarrhea in children. Methods A total of 189 children with rotavirus antigen were examined. Rotavirus positive children 106 cases were treated as observation group and rotavirus antigen negative children 83 cases as control group. Lactate dehydrogenase (LDH), aspartate aminotransferase (AST), isozymes (CK-MB), creatine kinase (CK) and a-hydroxybutyrate dehydrogenase 5 myocardial enzymes were detected, the level of myocardial enzymes was compared between two groups. Results Among the 106 cases of rotavirus infection in observation group, 72 patients had abnormal myocardial enzymes, the rate of which reached 67.92%. The myocardial enzymes of 83 children in the control group were all normal. The CK, AST , CK-MB, α-HBDH levels were significantly higher than the control group, the difference was significant. Conclusions Myocardial zymogram was correlated with rotavirus-induced diarrhea. Serum myocardial enzymes were detected in children, which could help to detect myocardial damage in infants and young children in time, providing the basis for the clinical diagnosis and treatment of the disease.