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动脉粥样硬化性疾病的发病率和病死率很高。以往的观点认为,内皮损伤引发炎症反应,导致动脉粥样硬化性病变。如今对于动脉粥样硬化的研究已经不局限于血管壁受损,它与内皮祖细胞的改变也存在很大的相关性。现就影响内皮祖细胞的危险因素,到内皮祖细胞减少及功能障碍的机制,再到斑块的形成,最后到临床症状的出现,综述了内皮祖细胞在动脉粥样硬化形成、发展过程中所起的作用。
The incidence and mortality of atherosclerotic disease is high. In the past, it was thought that endothelial injury triggers an inflammatory reaction that leads to atherosclerotic lesions. Nowadays, the research on atherosclerosis has not been limited to the damage of the blood vessel wall. It also has a great correlation with the change of endothelial progenitor cells. Now on the impact of endothelial progenitor cells risk factors to endothelial progenitor cells and dysfunction mechanism, and then to the formation of plaques, and finally to the emergence of clinical symptoms, reviewed endothelial progenitor cells in the formation and development of atherosclerosis The role played.