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目的探讨 1996～ 1999年副伤寒甲临床特点 ,提高诊治水平。方法回顾性分析副伤寒甲住院病例的临床特点并与同期伤寒病例作对比。结果副伤寒甲病例临床表现与近年伤寒病例相似 ,但早期症状不典型 ,易误诊 ,副伤寒甲杆菌对氯霉素、氨苄青霉素及庆大霉素敏感性与伤寒相比无显著性差异 ,但对氟哌酸、环丙沙星、菌必治、先锋必敏感性不如伤寒杆菌。使用环丙沙星或氧氟沙星疗效不及伤寒患者 ,治疗副伤寒甲单用喹诺酮类抗生素疗效不及喹诺酮类联用氨基糖甙类抗生素。结论诊断副伤寒甲有赖于实验室检查 ,对于单用喹诺酮类抗生素疗效不佳的副伤寒甲病例应尽早联用氨基糖甙类抗生素。规范抗生素的使用 ,对于延缓沙门菌耐药性有好处。
Objective To investigate the clinical characteristics of paratyphoid A from 1996 to 1999 and to improve the diagnosis and treatment. Methods The clinical features of paratyphosis A inpatients were retrospectively analyzed and compared with those of the same period. Results The clinical manifestations of paratyphoid A cases were similar to the cases of typhoid fever in recent years. However, the early symptoms were not typical and were easily misdiagnosed. There was no significant difference in the susceptibility of Paratyphoid to the susceptibility of chloramphenicol, ampicillin and gentamycin to typhoid Of norfloxacin, ciprofloxacin, bacteria must rule, Pioneer will be less susceptible to Salmonella typhi. The use of ciprofloxacin or ofloxacin less effective than typhoid fever patients, the treatment of patiENTs with single quinolone antibiotics less effective than quinolones combined with aminoglycoside antibiotics. Conclusions The diagnosis of paratyphoid fever depends on the laboratory tests. As for the paratyphoid patients with poor curative effect of quinolone antibiotics alone, aminoglycoside antibiotics should be used as early as possible. Regulating the use of antibiotics is good for delaying Salmonella resistance.