目的探讨脑垂体对细胞因子水平的影响。方法采用生物活性法检测去脑垂体大鼠血清细胞因子IL-2、IL-6、TNF水平及应用放射免疫分析法检测垂体GH、TSH、PRL水平。结果 SD大鼠切除脑垂体后血清中GH、TSH、PRL水平均显著下降，血清中细胞因子IL-2、TNF活性均显著性降低，但IL-6无明显改变。结论切除大鼠脑垂体后将影响了其免疫功能，证明脑垂体分泌正常的GH、TSH、PRL水平对维持正常的细胞因子水平有重要的作用。“,”Objective　To study the effects of pituitary gland on level of cytokines．Methods　The cytokines including IL-2，IL-6 and TNF was examined by determination method of bioassay．Level of serum growth hormone（GH），thyroid-stimulating hormone（TSH） and prolactin（PRL） were examined by radioimmunoassay in Spraque-Dawly（SD） rats．Results　In hypophysectomied Spraque-Dawly rats，level of serum GH，TSH and PRL are significantly decrease and the level of IL-2，TNF except IL-6 was markedly decreased．Conclusion　The anterior lobe of pituitary gland can effect level of IL-2，TNF．Normal level of GH，TSH，PRL is very important to maintain level of cytokines．