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5. A novel small molecule inhibitor targeted at Bcl-2

A novel small molecule inhibitor targeted at Bcl-2

来源 :中国科学：生命科学英文版 | 被引量 : 0次 | 上传用户：h563268898

【摘 要】

：

Recently, the heterocyclic compound 8-oxo-3-thiomorpholino-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile (S1) was synthesized and shown to induce apoptosis in both

【作 者】

：

JIN LiJi ZHANG ZhiChao WANG Yu 

【机 构】

：

SchoolofEnvironmental&,BiologicalScience&,Technology,StateKeyLaboratoryofElemento-organicChemi

【出 处】

：

中国科学：生命科学英文版

【发表日期】

：

2007年5期

【关键词】

：

apoptosis Bcl-2 small molecule HETEROCYCLIC COMPOUND apoptosis  Bcl-2  small 

【基金项目】

：

Supported by the National Natural Science Foundation of China (Grant No. 30400106)

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Recently, the heterocyclic compound 8-oxo-3-thiomorpholino-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile (S1) was synthesized and shown to induce apoptosis in both (H22) hematoma and (MCF-7) adenocarcinoma cells. The IC50 values of S1 against the two cell li

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