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为了观察甲型肝炎 (甲肝 )减毒活疫苗 (H2 株 ,10 6 5TCID50 /ml)不同加强程序的免疫效果 ,并探讨甲肝减毒活疫苗的优化免疫方案 ,于 1993年在浙江省台州市椒江区选择 2 6 4名经事先检测 (ELISA法 )抗 -HAV -IgG抗体阴性的儿童 ,按 4种不同加强程序 ,即在接种 1针后的 6个月、12个月、3年、6年接种第 2针。每次接种后 1个月采集血清标本 ,观察免疫后抗体阳转率及几何平均滴度 (GMT)。结果 :接种甲肝减毒活疫苗第 1针后 1个月抗 -HAV -IgG抗体阳转率为 92 2 %～ 10 0 0 % ,GMT为 1∶3 17～ 1∶5 15 (ELISA法 ) ;按 4种不同加强程序接种第 2针后 ,抗 -HAV -IgG抗体阳转率都达 10 0 0 % ,GMT都增长 >4倍 ;其中 0、6个月与 0、12个月加强程序GMT最高 ,达 1∶34 4 3～ 1∶35 12 (ELISA法 )或 30 6 9mIU/ml～ 3133mIU/ml(AbbottEIA法 )。甲肝减毒活疫苗加强接种后抗体GMT有大幅度提高 ,其中 0、6个月或 0、12个月程序值得推荐
In order to observe the immune effect of different intensified programs of live attenuated Hepatitis A vaccine (H2 strain, 1055IDID / ml) and explore the optimized immunization program of attenuated live attenuated hepatitis A vaccine, in 1993, Jiaojiang A total of 264 children who were tested negative for anti-HAV-IgG antibodies by ELISA were selected according to 4 different procedures: 6 months, 12 months, 3 years and 6 years Inoculation of the second needle. Serum samples were collected one month after inoculation, and the antibody positive rate and geometric mean titer (GMT) after immunization were observed. Results: The positive rate of anti-HAV-IgG antibody was 92 2% ~ 100% and the GMT was 1: 17 ~ 1:15 at 1 month after inoculation of live attenuated hepatitis A vaccine (ELISA). Anti-HAV-IgG antibody positive rate reached 100% and GMT increased by> 4-fold after the second needle was inoculated by 4 different reinforcing procedures. Among them, 0,6 months and 0,12 months enhanced the GMT Up to 1:34 4 3 ~ 1:35 12 (ELISA) or 30 6 9mIU / ml ~ 3133mIU / ml (AbbottEIA method). Live attenuated hepatitis A vaccine to enhance antibody GMT after vaccination has greatly increased, of which 0,6 months or 0,12 months of the program recommended