论文部分内容阅读
目的分析温州地区肠道病毒的病原学特征和流行趋势,为手足口病的预防和控制提供依据。方法采集临床诊断为手足口病患者咽拭子和肛拭子,用荧光定量RT-PCR对肠道病毒分型。结果 2010年-2012年共检测3 110例,肠道病毒阳性率为73.31%,EV71、CoxA16和未定型肠道病毒阳性率分别为57.33%、4.86%、11.13%。阳性病例男女性别比为1.74,0岁~4岁儿童阳性数占91.62%,发病较高月份为4月-7月。结论 2010年-2012年温州手足口病患者检出的肠道病毒主要为EV71,其感染率高于CoxA16,是引起温州重症病例的主要病原体。2012年未定型肠道病毒阳性率高于2010年和2011年,提示对未定型肠道病毒需引起足够重视。0岁~4岁儿童发病率最高,发病高峰期为春末夏初,呈明显季节性。
Objective To analyze the etiological characteristics and epidemiological trend of enterovirus in Wenzhou area and provide basis for the prevention and control of hand-foot-mouth disease. Methods Throat swab and anal swab in clinical diagnosis of hand-foot-mouth disease were collected, and the enterovirus was typed by fluorescence quantitative RT-PCR. Results A total of 3101 cases were detected in 2010-2012. The positive rate of enterovirus was 73.31%. The positive rates of EV71, CoxA16 and undetermined enterovirus were 57.33%, 4.86% and 11.13% respectively. The male-female ratio of positive cases was 1.74, while the positive numbers of children aged 0 to 4 years accounted for 91.62%. The higher morbidity was from April to July. Conclusions From 2010 to 2012, the majority of enterovirus detected by HFMD patients in Wenzhou was EV71, which was higher than CoxA16 and was the major cause of severe cases in Wenzhou. In 2012, the positive rate of undetermined enterovirus was higher than that in 2010 and 2011, which indicated that enough attention should be paid to undetermined enterovirus. 0-year-old to 4-year-old children the highest incidence, the peak incidence of late spring early summer, was significantly seasonal.