本文通过氨茶碱在小鼠体内应用后,小鼠脾细胞对ConA的增殖反应、诱生IL-2活性和小鼠脾细胞对外源性IL-2的反应性的变化情况,来观察氨茶碱的免疫调节作用。结果表明:按治疗剂量及治疗剂量的1/50应用氨茶碱,均抑制小鼠脾细胞对ConA的增殖反应,降低IL-2的活性,随着用药时间的延长抑制作用明显。应用不同剂量的氨茶碱可影响小鼠脾细胞对外源性IL-2的反应性,即应用治疗剂量时反应性增强,低剂量时反应性降低。 In this article, aminophylline was observed by aminophylline treatment in mice, and spleen cells in mice were subjected to changes in the proliferation of ConA, induced IL-2 activity, and reactivity to exogenous IL-2 in mouse spleen cells. Alkali immunomodulatory effects. The results showed that aminophylline inhibited the proliferation of ConA and reduced the activity of IL-2 in mice spleen cells at the dose of 1/50 of the therapeutic dose and therapeutic dose, and the inhibitory effect was prolonged with the prolonged administration of aminophylline. The use of different doses of aminophylline can affect the response of spleen cells to exogenous IL-2, that is, the response is increased when the therapeutic dose is applied, and the reactivity is decreased when the dose is low.